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Modeling simulations also suggest that universal screening is especially cost effective in populations with ahigh frequencyof the prevalence of SCD >0.2 to 0.5 per 1000 births . The threshold for screening for SCD (0.5 per 1000 births) in many countries inAfricafar exceeds the minimum threshold for cost-effectiveness for newborn screening.

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Ebola was discovered in 1976 near the Ebola River in what is now the Democratic Republic ofCongo. Since then, the virus has emerged periodically from its natural reservoir (which remains unknown) and infected people in several African countries. This map shows the distribution of the Ebola virus inAfricasince its discovery in 1976.

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Frequencies of β S alleles can vary considerably over relativelysmalldistances (Figure 1).24 For example, pilot newborn screening studies in the Democratic Republic of theCongohave indicated that thefrequencyof SS at birth varies by region from 0.8% to 1.7%,54 and in neighboring Rwanda and Burundi, thefrequencyis considerably lower, 0 ...